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ABT Abbott Laboratories. ABT is a macrolide antibacterial agent under development by Abbott Laboratories and Taisho Pharmaceutical Co Ltd for the potential treatment of bacterial infection []. Japanese phase II trials were expected to commence in June and a phase II trial is being designed for respiratory infections, with Abbott expecting filing in March []. The bioavailability of ABT in humans is unaffected by food [] and in a phase I, randomized, double-blind trial in healthy males only mild adverse effects, usually affecting the gastrointestinal system, were observed [].
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Colorimetric sensors and biosensors exhibit promising potential toward the detection of metallic cations, anions, organic dyes, drugs, pesticides and other toxic pollutants due to their easy fabrication, quick detection, and high sensitivity and selectivity, as well as easy naked-eye sensing. In this work, we present the recent advances since made in the fabrication of colorimetric sensors for the environmental monitoring of toxic pollutants. To understand the relationships between the type, structure, and functions of nanomaterials as building units and the sensing performance of the designed colorimetric sensors, the fabrication of several sensor platforms based on functional nanomaterials such as metal nanoparticles, metal oxides, quantum dots, two-dimensional nanozymes, organic probes, and Schiff bases are demonstrated and discussed. The sensing mechanisms of the considered colorimetric sensors based on the aggregation of nanoparticles, decomposition of nanoparticles, nanozymes, fluorescence on—off, ligand—receptor interactions, and photonic structures are introduced and discussed in detail. In addition, instrument-based colorimetric sensors and advanced colorimetric sensor products for high-performance environmental monitoring are presented.
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